Chemically modified siRNAs and their conjugates
نویسندگان
چکیده
منابع مشابه
Recent progress in chemically modified siRNAs.
RNA interference technology has become a powerful laboratory tool to study gene function. Small interfering RNAs (siRNAs) have provided unprecedented opportunities for the development of new therapeutics in human diseases. Unfortunately, siRNA duplexes are not optimal drug-like molecules. The problems for their effective application are fundamentally delivery, stability and off-target effects. ...
متن کاملsiRNAmod: A database of experimentally validated chemically modified siRNAs
Small interfering RNA (siRNA) technology has vast potential for functional genomics and development of therapeutics. However, it faces many obstacles predominantly instability of siRNAs due to nuclease digestion and subsequently biologically short half-life. Chemical modifications in siRNAs provide means to overcome these shortcomings and improve their stability and potency. Despite enormous ut...
متن کاملSilencing of genes responsible for polyQ diseases using chemically modified single-stranded siRNAs.
Polyglutamine (polyQ) diseases comprise a group of nine genetic disorders that are caused by the expansion of the CAG triplet repeat, which encodes glutamine, in unrelated single genes. Various oligonucleotide (ON)-based therapeutic approaches have been considered for polyQ diseases. The very attractive CAG repeat-targeting strategy offers selective silencing of the mutant allele by directly ta...
متن کاملChemically modified and nanostructured graphene
Aalto University, P.O. Box 11000, FI-00076 Aalto www.aalto.fi Author Mari Ijäs Name of the doctoral dissertation Chemically modified and nanostructured graphene Publisher School of Science Unit Department of Applied Physics Series Aalto University publication series DOCTORAL DISSERTATIONS 126/2013 Field of research Theoretical and Computational Physics Manuscript submitted 12 June 2013 Date of ...
متن کاملChemically modified tetracyclines pdf
Sepsis was induced by cecal ligation.Chemically modified tetracyclines CMTs are derivatives of tetracycline group of drugs which lack antimicrobial action but have potent host modulating affects.Chemically Modified Tetracyclines: An Emerging Host Modulatory Therapy. 1Sonakshi Gupta and 2 Vidya Dodwad. 1Postgraduate student III Yr, Department.of chemically modified tetracyclines CMTs on the prod...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Chinese Pharmaceutical Sciences
سال: 2012
ISSN: 1003-1057
DOI: 10.5246/jcps.2012.01.001